The following support gems are recommendations by GGG as listed in-game, and do not necessarily reflect optimal combinations or the views of the wiki.
Gem tier
Support gems
I
Murderous IntentMurderous IntentTier: 1 Level: 1 Cost & Reservation Multiplier: 120%Supports skills that can Empower skills other than themselves, causing skills they Empower to Cull enemies.Skills Empowered by Supported Skills have Culling StrikePlace into a Skill's Support Gem socket in the Skills Panel to apply its effects to that Skill. You cannot have multiple copies of the same Support Gem socketed at the same time.
PersistencePersistenceDuration Tier: 1 Level: 1 Cost & Reservation Multiplier: 120%Supports any skill that has a duration, making that duration longer.Supported Skills have 40% more Skill Effect DurationPlace into a Skill's Support Gem socket in the Skills Panel to apply its effects to that Skill. You cannot have multiple copies of the same Support Gem socketed at the same time.
PremeditationPremeditationTier: 1 Level: 1 Cost & Reservation Multiplier: 130%Supports skills that can Empower skills other than themselves, causing skills they Empower to deal more damage.Skills Empowered by Supported Skills deal 15% more DamagePlace into a Skill's Support Gem socket in the Skills Panel to apply its effects to that Skill. You cannot have multiple copies of the same Support Gem socketed at the same time.
II
Coming Soon
Coming Soon
Coming Soon
III
Coming Soon
Coming Soon
Coming Soon
Item acquisition
Mantra of Destruction has restrictions on where or how it can drop.